Antiestrogen
A substance that can prevent the full expression of estrogen. Antiestrogens act by exerting antagonistic effects on target tissues (androgens and progestogens act in this way) or by competing with estrogens for access to receptor sites located on the cell surface. For example, the drug tamoxifen (brand name: Nolvadex) is an antiestrogen that is used in the treatment of breast cancer and to reduce the breast cancer incidence in high-risk women.
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Any substance capable of preventing full expression of the biological effects of estrogenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as androgens and progestogens do, or by competing with estrogens at estrogen receptors at the cellular level ( e.g., tamoxifen).

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an·ti·es·tro·gen or chiefly Brit an·ti·oes·tro·gen -'es-trə-jən,Brit -'ēs- n a substance that inhibits the physiological action of an estrogen
an·ti·es·tro·gen·ic or chiefly Brit an·ti·oes·tro·gen·ic -.es-trə-'jen-ik,Brit -.ēs- adj

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an·ti·es·tro·gen (an″te-esґtrə-jen) a substance capable of inhibiting the biological effects of estrogens.

Medical dictionary. 2011.

Look at other dictionaries:

  • Antiestrogen — An antiestrogen is a substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics. External links * [http://www.cancer.gov/Templates/db alpha.aspx?CdrID=44813… …   Wikipedia

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  • antiestrogen — n. * * * …   Universalium

  • antiestrogen — an·ti·estrogen …   English syllables

  • antiestrogen — an•ti•es•tro•gen [[t]ˌæn tiˈɛs trə dʒən, ˌæn taɪ [/t]] n. med a drug or other substance that inhibits, counteracts, or modifies the biological effects of estrogen • Etymology: 1980–85 …   From formal English to slang

  • antiestrogen — A substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics …   English dictionary of cancer terms

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  • tamoxifen — /teuh mok seuh feuhn, fen /, n. Pharm. an antineoplastic drug, C26H29NO, that blocks the estrogen receptors on cancer cells, used in the treatment of breast cancer. [1970 75; perh. T(RANS) + AM(INO) + OXY 2 + PHEN(YL), with resp. of y and ph] * * …   Universalium

  • List of steroid abbreviations — The steroid hormones are referred to by various abbreviations in the biological literature. The purpose of this list is to give commonly used abbreviations for steroid hormones, with supporting references to the literature.cite journal… …   Wikipedia

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