- One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain. Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (Compazine), promazine (Robinul and Anectine), thioridazine (Seroquel), trifluoperazine (Stelazine) and triflupromazine (Robinul).
* * *A compound formerly used extensively for the treatment of intestinal nematodes in animals; without central nervous system depressant activity itself, it serves as the parent compound for synthesis of a large number of antipsychotic compounds, including chlorpromazine, thioridazine, perphenazine, and fluphenazine. SYN: dibenzothiazine, thiodiphenylamine.
* * *phe·no·thi·azine .fē-nō-'thī-ə-.zēn n1) a greenish yellow crystalline compound C12H9NS used as an anthelmintic and insecticide esp. in veterinary practice called also thiodiphenylamine2) any of various phenothiazine derivatives (as chlorpromazine) that are used as tranquilizing agents esp. in the treatment of schizophrenia
* * *phe·no·thi·a·zine (fe″no-thiґə-zēn) 1. a greenish, tasteless, tricyclic organic compound prepared by fusing diphenylamine with sulfur; used as a veterinary anthelmintic. Called also dibenzothiazine and thiodiphenylamine. 2. any of a group of antipsychotic agents derived from this structure, i.e., all sharing a three-ring structure in which two benzene rings are joined by a sulfur and a nitrogen atom. They are potent alpha-adrenergic and dopaminergic blocking agents, their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, analgesic, sedative, and antiemetic activity.
Medical dictionary. 2011.