Polycystic kidney disease
Genetic disorder characterized by the development of innumerable cysts in the kidneys. These cysts are filled with fluid, and replace much of the mass of the kidneys. This reduces kidney function, leading to kidney

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polycystic kidney disease n either of two hereditary diseases characterized by gradually enlarging bilateral cysts of the kidney which lead to reduced renal functioning:
a) a disease that is inherited as an autosomal dominant trait, is usu. asymptomatic until middle age, and is marked by side or back pain, hematuria, urinary tract infections, and nephrolithiasis
b) a disease that is inherited as an autosomal recessive trait, usu. affects infants or children, and results in renal failure

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either of two unrelated heritable disorders marked by cysts scattered throughout both kidneys. Autosomal dominant polycystic kidney disease (ADPKD, formerly called the adult form) is the most common renal cystic condition, with deterioration of renal function that may not be detectable until the third or fourth decade of life; it runs a variable course, with only some cases progressing to renal failure. Autosomal recessive polycystic kidney disease (ARPKD, formerly called the infantile form) may be congenital or may appear at any time during childhood and has a high perinatal mortality rate; almost all cases lead to hypertension. In older children it may be associated with cystic and fibrotic disease of the liver. A similar acquired disease sometimes accompanies end-stage renal disease and is called acquired cystic disease of kidney. Called also polycystic kidneys and polycystic renal d.

Autosomal dominant polycystic kidney disease viewed from the external surface (A) and bisected (B), the kidney showing marked enlargement and numerous dilated cysts. (C), Autosomal recessive polycystic kidney disease, characterized by smaller cysts and dilated channels at right angles to the cortical surface.


Medical dictionary. 2011.

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  • Polycystic kidney disease — Classification and external resources Polycystic kidneys ICD 10 Q …   Wikipedia

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  • polycystic kidney disease — noun kidney disease characterized by enlarged kidneys containing many cysts; often leads to kidney failure • Syn: ↑PKD • Hypernyms: ↑kidney disease, ↑renal disorder, ↑nephropathy, ↑nephrosis * * * noun : either of two he …   Useful english dictionary

  • polycystic kidney disease — noun Date: 1948 either of two hereditary diseases characterized by gradually enlarging bilateral cysts of the kidney which lead to reduced renal functioning or renal failure …   New Collegiate Dictionary

  • Polycystic kidney disease 2 — (autosomal dominant), also known as PKD2, is a human gene.cite web | title = Entrez Gene: PKD2 polycystic kidney disease 2 (autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5311|… …   Wikipedia

  • Polycystic kidney disease 1 — Schematische Darstellung von Polycystin 1 und Polycystin 2 an einer Zelle.[1] PKD1 (engl. Abk. für polycystic kidney disease 1 (autosomal dominant) = „polyzystische Nierenerkrankung 1 (autosomal dominant)“) ist ein Gen, das sowohl beim Menschen… …   Deutsch Wikipedia

  • autosomal dominant polycystic kidney disease — (ADPKD) see polycystic kidney d …   Medical dictionary

  • autosomal recessive polycystic kidney disease — (ARPKD) see polycystic kidney d …   Medical dictionary

  • Polycystic liver disease — Classification and external resources Micrograph showing a von Meyenburg complex, a bile duct hamartoma associated with polycystic liver disease. Trichrome stain …   Wikipedia

  • polycystic liver disease — any of several congenital conditions in which the liver develops cysts and sometimes Meyenburg complexes, often in association with polycystic kidney disease. An autosomal recessive type develops in childhood and can be rapidly fatal; an… …   Medical dictionary

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