Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy
A rapidly progressive, often fatal viral infection of the brain. Commonly abbreviated as PML. PML is believed to be due to the Jacob-Creutzfeldt (JC) papovavirus. The virus infects oligodendrocytes (support cells in the brain). The signs and symptoms of PML include headaches, memory loss, changes in mental status, speech and vision difficulties, loss of strength, limb weakness, seizures, partial paralysis and loss of coordination. The disease leads to coma and then to death.

* * *

progressive multifocal leukoencephalopathy n a progressive and fatal demyelinating disease of the central nervous system that typically occurs in immunosuppressed individuals due to loss of childhood immunity to a double-stranded DNA virus of the genus Polyomavirus (species JC polyomavirus) ubiquitous in human populations and that is characterized by hemianopia, hemiplegia, alterations in mental state, and eventually coma

* * *

opportunistic infection of the central nervous system by the JC virus, seen in immunocompromised persons and sometimes secondary to neoplastic conditions such as lymphosarcoma, lymphoblastic leukemia, or myelogenous leukemia. The demyelination is usually found in the white matter of the cerebral hemispheres but may rarely be seen in the brainstem and cerebellum.

Medical dictionary. 2011.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Progressive multifocal leukoencephalopathy — ] natalizumabcite web |url=http://www.newscientist.com/channel/health/dn8796.html |title=Potential risks of powerful MS drug are weighed health 02 March 2006 New Scientist |accessdate=2008 01 28 |format= |work=] , chemotherapy cite journal… …   Wikipedia

  • multifocal leukoencephalopathy — see PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY …   Medical dictionary

  • Leukoencephalopathy with vanishing white matter — Classification and external resources OMIM 603896 Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the… …   Wikipedia

  • Progressive multifokale Leukenzephalopathie — Klassifikation nach ICD 10 A81.2 Progressive multifokale Leukenzephalopathie …   Deutsch Wikipedia

  • Progressive multifokale Leukoenzephalopathie — Klassifikation nach ICD 10 A81.2 Progressive multifokale Leukenzephalopathie …   Deutsch Wikipedia

  • leukoencephalopathy — White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic …   Medical dictionary

  • Leukoencephalopathy — The term Leukoencephalopathy is a broad term for leukodystrophy like diseases (PMID 17414998). It is applied to all brain white matter diseases, whether their molecular cause is known. It can refer specifically to any of these… …   Wikipedia

  • Leucoencephalopathie multifocale progressive — Leucoencéphalopathie multifocale progressive La leucoencéphalopathie multifocale progressive ou LEMP désigne une affection démyélinisante de la substance blanche du système nerveux central observée au cours de l immunodépression cellulaire… …   Wikipédia en Français

  • Leucoencéphalopathie Multifocale Progressive — La leucoencéphalopathie multifocale progressive ou LEMP désigne une affection démyélinisante de la substance blanche du système nerveux central observée au cours de l immunodépression cellulaire profonde (SIDA en particulier, leucémies, Maladie… …   Wikipédia en Français

  • Leucoencéphalopthie multifocale progressive — Leucoencéphalopathie multifocale progressive La leucoencéphalopathie multifocale progressive ou LEMP désigne une affection démyélinisante de la substance blanche du système nerveux central observée au cours de l immunodépression cellulaire… …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”