Prostate cancer gene
One of the genes that influences the origin and/or progression of prostate cancer, cancer of the prostate gland. Prostate cancer genes are scattered around in the human genome. They have been found to date on chromosome Xq27-q28 (on the X chromosome in region Xq27-q28) and on chromosomes 1q25, 1q42.2-q43, 7p22, 8p22, 10q25, 11p11.2 and 17p11. A gene for hereditary prostate cancer, HPC1 (hereditary prostate cancer 1), has been identified on the long (q) arm of chromosome 1 in region 1q24-q25. The gene encodes the enzyme ribonuclease L (RNASEL), which acts as a tumor suppressor. Germline (hereditary) mutations in this gene result in hereditary prostate cancer. Another hereditary prostate cancer gene, HPCX (hereditary prostate cancer on the X), is on the X chromosome in region Xq27-q28. Together, HPC1 and HPCX together account for but a fraction of all prostate cancer. A bevy of other genes play a role in prostate cancer. These include the KAI1 antimetastasis gene on chromosome 11p11.2 and a gene predisposing to early-onset prostate cancer (PCAP) which has been mapped to chromosome 1 at some distance from the HPC1 gene.

Medical dictionary. 2011.

Look at other dictionaries:

  • Prostate cancer — is a disease in which cancer develops in the prostate, a gland in the male reproductive system. It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the prostate to other… …   Wikipedia

  • prostate cancer — Malignant tumour of the prostate gland. Prostate cancer commonly occurs in men over age 50. Symptoms include frequent or painful urination, blood in the urine, sexual dysfunction, swollen lymph nodes in the groin, and pain in the pelvis, hips,… …   Universalium

  • Prostate Cancer Foundation — The Prostate Cancer Foundation (PCF), formerly known as CaP CURE, is the world’s largest philanthropic source of support for prostate cancer research . Its goal is to discover better treatments and a cure for recurrent prostate cancer (cite… …   Wikipedia

  • Early prostate cancer antigen-2 — (EPCA 2) is a protein of which blood levels are elevated in prostate cancer. It appears to provide more accuracy in identifying early prostate cancer than the standard prostate cancer marker, PSA. EPCA 2 is not the name of a gene. EPCA 2 gets its …   Wikipedia

  • Hereditary prostate cancer — A genetic form of prostate cancer. The risk of prostate cancer is clearly genetic. Men with a father or brother with prostate cancer are twice as likely to develop prostate cancer as men with no affected relatives. The risk increases with… …   Medical dictionary

  • Cancer (maladie) — Cancer Pour les articles homonymes, voir Cancer (homonymie). Quand des cellules normales sont endommagées et qu e …   Wikipédia en Français

  • Cancer de la société — Cancer Pour les articles homonymes, voir Cancer (homonymie). Quand des cellules normales sont endommagées et qu e …   Wikipédia en Français

  • Cancer généralisé — Cancer Pour les articles homonymes, voir Cancer (homonymie). Quand des cellules normales sont endommagées et qu e …   Wikipédia en Français

  • Cancer de la prostate — Prostate et vésicules séminales (normales) Le cancer de la prostate est un cancer fréquent touchant la prostate, une glande de l appareil reproducteur de l homme. Le cancer se développe à partir des tissus de la prostate quand des cellules y… …   Wikipédia en Français

  • CANCER — Dans les organismes multicellulaires animaux ou végétaux, chaque cellule constitue une entité morphologiquement et fonctionnellement distincte mais qui est soumise à des mécanismes de contrôle et de régulation extrêmement rigoureux. En fait, sa… …   Encyclopédie Universelle

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”