Proto-oncogene
A normal gene involved in cell division or proliferation which, when altered by mutation, becomes an oncogene that can contribute to cancer.

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pro·to-on·co·gene .prōt-ō-'äŋ-kə-.jēn n a gene having the potential for change into an active oncogene

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n.
a gene in a normal cell that is of identical structure to certain viral genes. Some are important regulators of cell division and damage may change them into oncogene.

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pro·to-on·co·gene (pro″to-ongґko-jēn) a normal cellular gene that with alteration, such as by mutation, DNA rearrangement, or nearby insertion of viral DNA, becomes an active oncogene; most proto-oncogenes are believed to normally function in cell growth and differentiation. See also oncogene.

Medical dictionary. 2011.

Look at other dictionaries:

  • Proto-oncogène — Oncogène Les oncogènes sont une des trois grandes catégories de gènes associées aux pathologies cancéreuses. Ce sont des gènes qui déclenchent une prolifération désordonée des cellules. Sommaire 1 Introduction 2 Les oncogènes 2.1 Un peu de …   Wikipédia en Français

  • proto-oncogene — proto oncogene. См. протоонкоген. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • proto-oncogene — noun a normal gene that has the potential to become an oncogene • Hypernyms: ↑gene, ↑cistron, ↑factor * * * ˌ noun Etymology: prot + oncogene : a gene having the potential for change into an active oncogene * * * /proh toh ong keuh jeen /, n. a… …   Useful english dictionary

  • proto-oncogene — The normal, cellular equivalent of an oncogene; thus usually a gene involved in the signalling or regulation of cell growth. In general, cellular proto oncogenes are prefixed with a ‘c’, rather than their abnormal viral counterparts, that are… …   Dictionary of molecular biology

  • proto-oncogene — A normal gene that can be mutated to an oncogene. Synonym: cellular oncogene …   Glossary of Biotechnology

  • proto-oncogene — /proh toh ong keuh jeen /, n. a normally present gene that appears to have a role in the regulation of normal cell growth, but that is converted to an oncogene by mutation. * * * …   Universalium

  • proto-oncogene — noun A gene, that promotes the specialization and division of normal cells, that becomes an oncogene following mutation …   Wiktionary

  • proto-oncogene — pro·to oncogene …   English syllables

  • proto-oncogene — n. a gene in a normal cell that is of identical structure to certain viral genes. Some are important regulators of cell division and damage may change them into oncogenes …   The new mediacal dictionary

  • RET proto-oncogene — The RET proto oncogene encodes a receptor tyrosine kinase for members of the glial cell line derived neurotrophic factor family of extracellular signalling molecules.cite journal | author = Knowles PP, Murray Rust J. et al | title = Structure and …   Wikipedia

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