Reverse genetics
In classic genetics, the traditional approach was to find a gene product and then try to identify the gene itself. In molecular genetics, the reverse has been done by identifying genes purely on the basis of their position in the genome with no knowledge whatsoever of the gene product. This revolutionary approach is reverse genetics. Also called positional cloning.

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reverse genetics n pl but sing in constr genetics that is concerned with genetic material whose nucleotide sequence is known and that analyzes its contribution to the phenotype of the organism by varying the nucleotide sequence and observing the results of such variation in the living organism, in living cells, or in vitro on macromolecules
reverse-genetic adj

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a branch of molecular genetics that proceeds in the opposite direction from traditional molecular genetics (sometimes in contrast called forward genetics); instead of proceeding from a phenotype of interest to identification of the gene or genes responsible, it begins with alteration of a specific gene and examines the resulting phenotypic effects.

Medical dictionary. 2011.

Look at other dictionaries:

  • reverse genetics — reverse genetics. См. обратная генетика. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Reverse genetics — is an approach to discovering the function of a gene that proceeds in the opposite direction of so called forward genetic screens of classical genetics. Simply put, while forward genetics seeks to find the genetic basis of a phenotype or trait,… …   Wikipedia

  • reverse genetics — singular noun The process of removing a gene from an organism, treating it in a known way, reinserting it, and testing the organism for any altered function • • • Main Entry: ↑reverse …   Useful english dictionary

  • reverse genetics — noun The practice of finding functions of known genes. Ant: forward genetics …   Wiktionary

  • reverse genetics — The technique of determining a gene s function by first sequencing it, then mutating it, and then trying to identify the nature of the change in the phenotype …   Dictionary of molecular biology

  • reverse genetics — See: positional cloning …   Glossary of Biotechnology

  • reverse mutation — reverse mutation. См. обратная мутация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • reverse mutation — reverse mutation. = back mutation (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • reverse selection — reverse selection. См. ревертивный отбор. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • reverse transcriptase — reverse transcriptase. См. ревертаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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