Rhabdomyolysis
A condition in which skeletal muscle cells break down, releasing myoglobin (the oxygen-carrying pigment in muscle) together with enzymes and electrolytes from inside the muscle cells. The risks with rhabdomyolysis include muscle breakdown and kidney failure since myoglobin is toxic to the kidneys. Rhabdomyolysis most often occurs as the result of extensive muscle damage as, for example, from a crushing injury or electrical shock. Drugs or toxins, particularly some of the cholesterol lowering medications such as cerivastatin (Baycol), may cause this disorder. Underlying diseases such as systemic lupus erythematosus can also lead to rhabdomyolysis.
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An acute, fulminating, potentially fatal disease of skeletal muscle that entails destruction of muscle, as evidenced by myoglobinemia and myoglobinuria. [rhabdo- + G. mys, muscle, + lysis, loosening]
- acute recurrent r. [MIM*268200] repeated paroxysmal attacks of muscle pain and weakness followed by passage of dark red-brown urine, often precipitated by intercurrent illness and diagnosed by demonstration of myoglobin in the urine; it is attributed to abnormal phosphorylase activity in skeletal muscle, but there may be more than one biologic type; probably autosomal recessive inheritance. In some cases, at least, there is deficiency of carnitine palmitoyl transferase. SYN: familial paroxysmal r..
- exertional r. r. produced in susceptible individuals by muscular exercise.

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rhab·do·my·ol·y·sis .rab-dō-mī-'äl-ə-səs n, pl -y·ses -.sēz the destruction or degeneration of skeletal muscle tissue (as from traumatic injury, excessive exertion, or stroke) that is accompanied by the release of muscle cell contents (as myoglobin and potassium) into the bloodstream resulting in hypovolemia, hyperkalemia, and sometimes acute renal failure

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rhab·do·my·ol·y·sis (rab″do-mi-olґĭ-sis) [rhabdo- + myo- + -lysis] disintegration or dissolution of muscle, associated with excretion of myoglobin in the urine.

Medical dictionary. 2011.

Look at other dictionaries:

  • Rhabdomyolysis — Classification and external resources Urine from a person with rhabdomyolysis showing the characteristic brown discoloration as a result of myoglobinuria …   Wikipedia

  • rhabdomyolysis — noun The rapid disintegration of striated muscle tissue accompanied by the excretion of myoglobin in the urine. Add another problem to the long list of issues stirring conflict between Coach Mike Shanahan and defensive lineman Albert Haynesworth …   Wiktionary

  • rhabdomyolysis — noun Etymology: New Latin, from rhabdo + my + lysis Date: 1956 the destruction or degeneration of muscle tissue (as from traumatic injury, excessive exertion, or stroke) accompanied by the release of breakdown products into the bloodstream and… …   New Collegiate Dictionary

  • rhabdomyolysis — n. (Medicine) disintegration of skeletal muscle tissue as a result of electrocution or prolonged exposure to toxins (characterized by excretion of myoglobin in the urine) …   English contemporary dictionary

  • rhabdomyolysis — [ˌrabdə(ʊ)mʌɪ ɒlɪsɪs] noun Medicine the destruction of striated muscle cells. Origin 1950s: from Gk rhabdos rod + myo + lysis …   English new terms dictionary

  • rhabdomyolysis — rhab·do·my·ol·y·sis …   English syllables

  • rhabdomyolysis — ¦rabdōmīˈäləsə̇s noun (plural ses) Etymology: New Latin, from rhabd + my + lysis : the destruction or degeneration of skeletal muscle tissue (as from traumatic injury, excessive exertion, or stroke) that is accompanied by the release of muscle… …   Useful english dictionary

  • Equine Exertional Rhabdomyolysis — (ER) or Tying Up or Azoturia or Monday Morning Disease is a syndrome that damages the muscle tissue in horses. It is usually due to overfeeding a horse carbohydrates and appears to have a genetic link.Causes and Process of ERBeyond a highly… …   Wikipedia

  • Equine exertional rhabdomyolysis — (ER, also known as tying up, azoturia, or Monday morning disease) is a syndrome that damages the muscle tissue in horses. It is usually due to overfeeding a horse carbohydrates and appears to have a genetic link. Contents 1 Causes and process of… …   Wikipedia

  • exertional rhabdomyolysis — 1. rhabdomyolysis due to intense, prolonged physical exertion, with symptoms often resembling those elicited by exercise in persons with occlusive arterial disease. 2. severe muscular soreness and recumbency in an animal during exercise, either… …   Medical dictionary

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