ACE inhibitor
A drug that inhibits ACE (angiotensin converting enzyme) which is important to the formation of angiotensin II. Angiotensin II causes arteries in the body to constrict and thereby raises the blood pressure. ACE inhibitors lower the blood pressure by inhibiting the formation of angiotensin II. This relaxes the arteries. Relaxing the arteries not only lowers blood pressure, but also improves the pumping efficiency of a failing heart and improves cardiac output in patients with heart failure. ACE inhibitors are therefore used for blood pressure control and congestive heart failure. The currently available ACA inhibitors include: {{}}benazepril (brand name: LOTENSIN), captopril (brand name: CAPOTEN), lisinopril (brand names: ZESTRIL and PRINIVIL), quinapril (brand name: ACCUPRIL), and ramipril (brand name: ALTACE). ACE inhibitors may slow the progress of diabetic kidney disease in middle-aged persons with type 2 diabetes. Some (but not all) experts have therefore recommended giving ACE inhibitors to all middle-aged type 2 diabetics. (Reference: Annals of Internal Medicine 1999;131:660-667, 707-708.) Historically, it is interesting that the ACE inhibitors were originally developed from the venom of a poisonous Brazilian snake.

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ACE inhibitor 'ās-, .ā-(.)sē-'ē- n any of a group of antihypertensive drugs (as captopril) that relax arteries and promote renal excretion of salt and water by inhibiting the activity of an angiotensin converting enzyme

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angiotensin-converting enzyme inhibitor: any one of a group of drugs used in the treatment of raised blood pressure and heart failure. ACE inhibitors act by interfering with the action of the enzyme that converts the inactive angiotensin I to the powerful artery constrictor angiotensin II. The absence of this substance allows arteries to widen and the blood pressure to drop. ACE inhibitors are administered by mouth; they include captopril, enalapril, perindopril (Coversyl), and ramipril (Tritace). Possible side-effects include weakness, dizziness, loss of appetite, and skin rashes.

Medical dictionary. 2011.

Look at other dictionaries:

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  • ACE inhibitor — [ā΄sē΄ē′, ās] n. [a( ngiotensin ) c( onverting) e( nzyme)] any of a class of drugs, including captopril, that inhibit or block the action of an enzyme (ACE) that produces the powerful vasoconstrictor angiotensin, used to treat high blood pressure …   English World dictionary

  • ACE inhibitor — noun an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to …   Useful english dictionary

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  • ACE inhibitor — ACE′ inhib itor [[t]eɪs, ˈeɪˈsiˈi[/t]] n. pha med any of a group of vasodilator drugs used in the treatment of hypertension and heart failure • Etymology: 1980–85; A(ngiotensin) C(onverting) E(nzyme) …   From formal English to slang

  • ACE inhibitor — angiotensin converting enzyme inhibitor: any one of a group of drugs used in the treatment of raised blood pressure and heart failure. ACE inhibitors act by interfering with the action of the enzyme that converts the inactive angiotensin I to the …   The new mediacal dictionary

  • ACE inhibitor — noun Etymology: angiotensin converting enzyme Date: 1982 any of a group of antihypertensive drugs (as captopril) that relax arteries and promote renal excretion of salt and water by inhibiting the activity of angiotensin converting enzyme …   New Collegiate Dictionary

  • ACE inhibitor — /ays, ay see ee / any of a group of vasodilator drugs used in the treatment of hypertension and heart failure. [1980 85; A(ngiotensin) C(onverting) E(nzyme)] * * * …   Universalium

  • ACE inhibitor — noun / eɪs ən.hɪ.bɪ.toɹ/lang=en any one of a class of drugs, including captopril and enalpapril, that cause the arteries to widen by preventing the synthesis on angiotensin: used to treat high blood pressure and heart failure …   Wiktionary

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