Sickle hemoglobin
Hemoglobin S, the most common type of abnormal hemoglobin and the basis of both sickle cell trait and sickle cell anemia. Hemoglobin S differs from normal adult hemoglobin (hemoglobin A) only by a single amino acid substitution (There is the substitution of the amino acid valine for the amino acid glutamine in the 6th position of the beta chain of globin). Recognition of this tiny change in the hemoglobin molecule marked the opening of the era of molecular medicine.

Medical dictionary. 2011.

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  • Sickle cell trait — Infobox Disease Name = Sickle cell trait Caption = DiseasesDB = ICD10 = ICD10|D|57|3|d|55 ICD9 = ICDO = OMIM = 603903 MedlinePlus = 000527 eMedicineSubj = search eMedicineTopic = Sickle%20cell MeshID = Sickle cell trait describes the way a person …   Wikipedia

  • Sickle cell disease — A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest reaches of the body. Sickle cell disease, also …   Medical dictionary

  • Sickle cell anemia — A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body. Sickle cell anemia affects… …   Medical dictionary

  • sickle — sick·le sik əl n a dental scaler with a curved 3 sided point sickle adj of, relating to, or characteristic of sickle cell anemia or sickle cell trait <sickle hemoglobin> sickle vb, sick·led; sick·ling sik (ə )liŋ vt to change (a red blood… …   Medical dictionary

  • Hemoglobin — Hemoglobin, human, adult (heterotetramer, (αβ)2) Structure of human hemoglobin. The protein s α and β subunits are in red and blue, and the iron containing heme groups in green. Fro …   Wikipedia

  • sickle cell trait — ☆ sickle cell trait n. the heterozygous condition of having one gene for sickle cell hemoglobin and one for normal hemoglobin: ordinarily this does not cause anemia or sicklemia …   English World dictionary

  • sickle cell — n 1) an abnormal red blood cell of crescent shape 2) a condition characterized by sickle cells: SICKLE CELL ANEMIA, SICKLE CELL TRAIT * * * see drepanocyte * * * an erythrocyte shaped like a sickle or crescent owing to the presence of …   Medical dictionary

  • sickle cell anemia disease — ☆ sickle cell anemia disease n. an inherited chronic anemia found chiefly among blacks, characterized by an abnormal red blood cell (sickle cell) containing a defective form of hemoglobin that causes the cell to become sickle shaped when deprived …   Universalium

  • sickle cell anemia disease — ☆ sickle cell anemia disease n. an inherited chronic anemia found chiefly among blacks, characterized by an abnormal red blood cell (sickle cell) containing a defective form of hemoglobin that causes the cell to become sickle shaped when deprived …   English World dictionary

  • sickle-cell anemia — n a chronic anemia that occurs in individuals (as those of African or Mediterranean descent) who are homozygous for the gene controlling hemoglobin S and that is characterized by destruction of red blood cells and by episodic blocking of blood… …   Medical dictionary

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