Syndrome, antiphospholipid antibody
An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts (thrombocytopenia). The abnormal antibodies are directed against phospholipids. (Phospholipids are fats that contains phosphorous). APLS can occur by itself (primary) or be caused by an underlying condition (secondary), such as systemic lupus erythematosus. About a third of persons with primary APLS have heart valve abnormalities. Antiphospholipid antibodies reduce the levels of annexin V, a protein that binds phospholipids and has potent anticoagulant activity. The reduction of annexin V levels is thought to be a possible mechanism underlying the increased tendency of blood to clot and the propensity to pregnancy loss characteristic of the antiphospholipid antibody syndrome.

Medical dictionary. 2011.

Look at other dictionaries:

  • Antiphospholipid antibody syndrome (APLS) — An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts… …   Medical dictionary

  • antiphospholipid antibody syndrome — an autoimmune disease in which the presence of antibody against phospholipid is associated with a tendency to thrombosis and in women of childbearing age recurrent (three or more) miscarriages. In pregnant women blood clots form in the placenta,… …   Medical dictionary

  • antiphospholipid antibody syndrome — APS; = Hughes syndrome an autoimmune disease in which the presence of antibodies against phospholipid is associated with a tendency to arterial or venous thrombosis and – in women of childbearing age – recurrent miscarriage. APS may be primary or …   The new mediacal dictionary

  • APLS (antiphospholipid antibody syndrome) — An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts… …   Medical dictionary

  • Antiphospholipid syndrome — Classification and external resources Micrograph showing an advanced thrombotic microangiopathy, as may be seen in ALPA syndrome. Kidney biopsy. PAS stain …   Wikipedia

  • Syndrome des antiphospholipides — Classification et ressources externes CIM 10 D68.8 (ILDS D68.810) CIM 9 ICD9 289.81 OMIM 107320 Dis …   Wikipédia en Français

  • antiphospholipid syndrome — antiphospholipid antibody syndrome (APS) a multisystem inflammatory disorder characterized by the presence of circulating antiphospholipid antibodies with thrombosis (including thrombotic microangiopathy), spontaneous abortion, thrombocytopenia,… …   Medical dictionary

  • Antiphospholipid-Syndrom — Klassifikation nach ICD 10 D68.6 Sonstige Thrombophilien …   Deutsch Wikipedia

  • syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… …   Medical dictionary

  • antibody — An immunoglobulin molecule produced by B lymphoid cells with a specific amino acid sequence evoked in humans or other animals by an antigen (immunogen). These molecules are characterized by reacting specifically with the antigen in some… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”