Syndrome, Li-Fraumeni (LFS)
This is an extraordinary cancer family syndrome. People with LFS have a tendency to develop a great diversity of tumors. LFS was first discovered in 1969. By reviewing the medical records and death certificates of children with a relatively rare tumor, a soft tissue sarcoma called rhabdomyosarcoma, Drs. Fred Li and Joe Fraumeni at the National Cancer Institute identified several families in which siblings or cousins also had a childhood sarcoma. These same families had exceptional histories of breast cancer and other tumors and proved to have LFS. The spectrum of cancers in LFS has been shown to include breast cancer, soft tissue sarcomas, brain tumors, a bone tumor called osteosarcoma, leukemia, and a tumor of the adrenal gland (adrenocortical carcinoma): an incredible range of malignancies. The Li-Fraumeni syndrome has been found to be due to a mutation (a heritable change) in a gene that normally serves to curb cancer: the p53 tumor-suppressor gene. LFS has been of considerable importance to the understanding of the genetics and molecular biology of cancer.

Medical dictionary. 2011.

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  • Li-Fraumeni syndrome — Infobox Disease Name = Li Fraumeni syndrome Caption = DiseasesDB = 7450 ICD10 = ICD9 = ICD9|758.3 ICDO = OMIM = 151623 MedlinePlus = eMedicineSubj = ped eMedicineTopic = 1305 MeshID = D016864 Li Fraumeni syndrome is a rare autosomal dominant… …   Wikipedia

  • Li-Fraumeni syndrome (LFS) — This is an extraordinary cancer family syndrome. People with LFS have a tendency to develop a great diversity of tumors. LFS was first discovered in 1969. By reviewing the medical records and death certificates of children with a relatively rare… …   Medical dictionary

  • LFS — lateral facet syndrome; latest finishing shift; Li Fraumeni syndrome; limbic forebrain structure; liver function series …   Medical dictionary

  • LFS — • lateral facet syndrome; • latest finishing shift; • Li Fraumeni syndrome; • limbic forebrain structure; • liver function series …   Dictionary of medical acronyms & abbreviations

  • Gen supresor tumoral — Un gen supresor tumoral es un gen que reduce la probabilidad de que una célula en un organismo multicelular se transforme en una célula cancerígena.[1] Los genes supresores de tumores se encuentran en las células normales y normalmente inhiben la …   Wikipedia Español

  • Tumor suppressor gene — A tumor suppressor gene, or antioncogene is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with… …   Wikipedia

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