Syndrome, Zollinger-Ellison
A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine (the duodenum and jejunum). Gastrinomas resulting in the Zollinger-Ellison syndrome are not limited to the pancreas but may also occur in the stomach, duodenum, spleen and lymph nodes. The treatment of the Zollinger-Ellison syndrome includes the use of H2 antagonists (for example cimetidine [brand name: Tagamet] and ranitidine [Zantac]) and the proton pump inhibitors (for example, lansoprazole [Prevacid] and omeprazole [Prilosec]). The H2 antagonists block the action of histamine on stomach cells, thus reducing stomach acid production. The proton pump inhibitors also block the production of acid by the stomach cells. Surgical removal of the tumor is curative in about 25% of cases. The syndrome is named for two American surgeons Robert M. Zollinger (1903-1992) and Edwin H. Ellison (1918-1970).

Medical dictionary. 2011.

Look at other dictionaries:

  • Syndrome de zollinger-ellison — Le syndrome de Zollinger Ellison est un syndrome paranéoplasique caractérisé par des ulcères digestifs graves, souvent multiples, résistant aux traitements usuels, avec hypersécrétion et hyperacidité importante de la muqueuse gastrique. Ces… …   Wikipédia en Français

  • ZOLLINGER-ELLISON (SYNDROME DE) — ZOLLINGER ELLISON SYNDROME DE Le syndrome de Zollinger Ellison est une affection endocrinienne caractérisée par une hyperproduction de gastrine du fait d’une tumeur (plus souvent maligne que bénigne) ou d’une hyperplasie endocrine siégeant le… …   Encyclopédie Universelle

  • syndrome de Zollinger-Ellison — ● syndrome de Zollinger Ellison Affection caractérisée par une hypersécrétion gastrique, des ulcères duodénaux d évolution grave, et une diarrhée, en rapport avec une tumeur pancréatique des îlots de Langerhans …   Encyclopédie Universelle

  • Zollinger-Ellison-Syndrom — Klassifikation nach ICD 10 E16.4 Abnorme Gastrinsekretion Zollinger Ellison Syndrom …   Deutsch Wikipedia

  • Zollinger-Ellison syndrome — Infobox Disease Name = PAGENAME Caption = Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger Ellison syndrome DiseasesDB = ICD10 = ICD10|E|16|4|e|15 ICD9 = ICD9|251.5 ICDO = OMIM = MedlinePlus = 000325… …   Wikipedia

  • Zollinger-Ellison syndrome — A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach,… …   Medical dictionary

  • Syndrome de Zollinger-Ellison — Le syndrome de Zollinger Ellison est un syndrome paranéoplasique caractérisé par des ulcères digestifs graves, souvent multiples, résistant aux traitements usuels, avec hypersécrétion et hyperacidité importante de la muqueuse gastrique. Ces… …   Wikipédia en Français

  • Zollinger-Ellison syndrome — noun syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity • Hypernyms: ↑syndrome * * * ¦zäliŋər¦elə̇sən noun Usage: usually capitalized Z&E Etymology: after Robert M. Zollinger died 1992 and Edwin H.… …   Useful english dictionary

  • Zollinger-Ellison syndrome — /zol ing euhr el euh seuhn/, Pathol. a condition in which a gastrin secreting tumor of the pancreas or small intestine causes excessive secretion of gastric juice, leading to intractable peptic ulcers. [after Robert Milton Zollinger (born 1903)… …   Universalium

  • Zollinger-Ellison syndrome — a rare disorder in which there is excessive secretion of gastric juice due to high levels of circulating gastrin, which is produced by a pancreatic tumour (see gastrinoma) or an enlarged pancreas. The high levels of stomach acid cause diarrhoea… …   The new mediacal dictionary

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