first messenger

first messenger
first messenger n an extracellular substance (as the hormone epinephrine or the neurotransmitter serotonin) that binds to a cell-surface receptor and initiates intracellular activity compare SECOND MESSENGER

* * *

a factor or hormone that binds to a receptor on the external surface of a cell and sets off a series of reactions that eventually convert a precursor into a second messenger.

Medical dictionary. 2011.

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