granulocyte-macrophage colony-stimulating factor
- granulocyte-macrophage colony-stimulating factor
granulocyte-macrophage colony-stimulating factor n a colony-stimulating factor produced by T cells, macrophages, endothelial cells, and fibroblasts that promotes the differentiation of bone marrow stem cells, stimulates the maturation of precursor cells into granulocytes and macrophages, and activates mature macrophages
abbr. GM-CSF see SARGRAMOSTIM
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(GM-CSF) a colony-stimulating factor, secreted by activated T lymphocytes and macrophages and by stimulated endothelial cells, that binds to a specific receptor found on stem cells and most myelocytes and stimulates their differentiation into granulocytes and macrophages. GM-CSF also enhances the function of mature granulocytes and macrophages in vitro. A recombinant form used therapeutically is called sargramostim.
Medical dictionary.
2011.
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