- One of a group of drugs with antipsychotic activity which act by blocking postsynaptic (after-the-nerve) receptors for dopamine (a chemical that nerves use to communicate with one another) in the brain. Examples include: thiothixene (brand name: Navane), chlorprothixene (Remeron) and flupenthixol.
* * *A class of tricyclic compounds resembling phenothiazine, but with the central ring nitrogen replaced by a carbon atom; current use emphasizes the antipsychotic and antiemetic properties of this class.
* * *thio·xan·thene .thī-ō-'zan-.thēn n a compound C13H10S that is the parent compound of various antipsychotic drugs (as thiothixene) also a derivative of thioxanthene
* * *n.
* * *thio·xan·thene (thi″o-zanґthēn) 1. a three-ring compound structurally related to phenothiazine but having the nitrogen atom at position 10 replaced by a carbon atom with a double bond. 2. any of a class of structurally related antipsychotic agents derived from thioxanthene, including flupenthixol and thiothixene.
Medical dictionary. 2011.