- A plasma protein that transports iron through the blood to the liver, spleen and bone marrow. The blood transferrin level is tested for diverse reasons: to determine the cause of anemia, to examine iron metabolism (for example, in iron deficiency anemia) and to determine the iron-carrying capacity of the blood. Low transferrin can impair hemoglobin production (since to make hemoglobin, you have to have iron) and so lead to anemia. Low transferrin can be due to poor production of transferrin by the liver (where it's made) or excessive loss of transferrin through the kidneys into the urine. Many conditions including infection and malignancy can depress transferrin levels. The transferrin is abnormally high in iron deficiency anemia. The gene for transferrin is in chromosome band 3q21. Hereditary absence of transferrin is called atransferrinemia. It is characterized by anemia and hemosiderosis (iron deposition) in the heart and liver. The iron damage to the heart can lead to heart failure. The anemia is typically microcytic and hypochromic (the red blood cells are abnormally small and pale). The disease is inherited as an autosomal recessive trait. It is due to mutation of both of a person's transferrin genes. Atransferrinemia can be effectively treated by plasma infusions of transferrin.
* * *1. A nonheme β1-globulin of the plasma, capable of associating reversibly with up to 1.25 μg of iron per gram, and acting therefore as an iron-transporting protein. 2. A glycoprotein, found in mammalian milk (lactoferrin) and egg white (conalbumin, ovotransferrin), that binds and transports iron (Fe3+). [trans- + L. ferrum, iron, + -ia]
* * *trans·fer·rin tran(t)s-'fer-ən n a beta globulin in blood plasma capable of combining with ferric ions and transporting iron in the body called also siderophilin
* * *n.a glycoprotein, found in the blood plasma, that is capable of binding iron and thus acts as a carrier for iron in the bloodstream.
* * *trans·fer·rin (trans-ferґin) [trans- + ferrum + -in chemical suffix] a nonheme serum glycoprotein of molecular weight 79,500, which binds and transports iron; most is produced in the liver. A similar substance called apoferritin is produced in the small intestine. Called also siderophilin.
Medical dictionary. 2011.