Trimethylaminuria (TMA)
An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of TMA in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate) and severe hypertension (high blood pressure) after eating cheese (which contains tyramine) and after using nasal sprays containing epinephrine. TMA is caused by a mutation (change) in the gene for an enzyme, flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3 enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with various psychosocial reactions, including social isolation, clinical depression and attempted suicide.

Medical dictionary. 2011.

Look at other dictionaries:

  • Trimethylaminuria — Classification and external resources Trimethylamine ICD 10 E88.8 …   Wikipedia

  • Fish-odor syndrome — An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate)… …   Medical dictionary

  • Syndrome, fish-odor — An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate)… …   Medical dictionary

  • Trimetilaminuria — Estructura de la trimetilamina Clasificación y recursos externos CIE 10 E …   Wikipedia Español

  • Trimethylamine — Trimethylamine[1] …   Wikipedia

  • Trimethylamine N-oxide — chembox new ImageFile=Trimethylaminoxid.svg ImageSize= 150 IUPACName= trimethylamine oxide OtherNames= trimethylamine oxide, TMAO, TMANO Section1=Chembox Identifiers CASNo= 1184 78 7 PubChem= 24859089 SMILES= Section2=Chembox Properties C=3 | H …   Wikipedia

  • Triméthylaminurie — Classification et ressources externes CIM 10 E88.8 …   Wikipédia en Français

  • Flavin containing monooxygenase 1 — Flavin containing monooxygenase 1, also known as FMO1, is a human gene.cite web | title = Entrez Gene: FMO1 flavin containing monooxygenase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2326| accessdate …   Wikipedia

  • FMO5 — Flavin containing monooxygenase 5, also known as FMO5, is a human gene. PBB Summary section title = summary text = Metabolic N oxidation of the diet derived amino trimethylamine (TMA) is mediated by flavin containing monooxygenase and is subject… …   Wikipedia

  • FMO4 — Flavin containing monooxygenase 4, also known as FMO4, is a human gene.cite web | title = Entrez Gene: FMO4 flavin containing monooxygenase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2329| accessdate …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”