Variant Creutzfeldt-Jakob disease
Abbreviated vCJD. A human disease thought due to the same infectious agent as bovine spongiform encephalopathy (BSE), or mad cow disease. Both the human and bovine disorders are invariably fatal brain diseases with unusually long incubation periods measured in years, and are caused by an unconventional transmissible agent, a prion, resulting in the deposition of amyloid tissue that causes a breakdown of brain tissue leaving the infected brain with a "spongy" ("spongiform") appearance. The disease in humans is sometimes called new variant Creutzfeldt-Jakob disease (nvCJD). The BSE agent has been identified in the brain, spinal cord, retina, dorsal root ganglia (nervous tissue located near the backbone), and the bone marrow of cattle experimentally infected with this agent by the oral route. In addition to cattle, sheep are susceptible to experimental infection with the BSE agent by the oral route. Thus, in countries where flocks of sheep and goats may have been exposed to the BSE agent through contaminated feed, there exists a theoretical risk that these animals may have developed infections caused by the BSE agent and that these infections have been maintained in the flocks, even in the absence of continued exposure to contaminated feed (for example, through maternal transmission). Everyone with vCJD appear to have eaten beef and beef products at some time during their lives (but then so have most of the population). Investigation of a cluster of cases with vCJD in the UK disclosed that most of the people were likely infected through their diet. Beef carcass meat appears to have been contaminated with the BSE agent in butchers' shops where cattle heads were split.

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variant Creutzfeldt-Jakob disease n a fatal spongiform encephalopathy that is held to be a variant of Creutzfeldt-Jakob disease caused by the prion associated with bovine spongiform encephalopathy and contracted by consuming infected beef or beef products abbr. vCJD called also new variant Creutzfeldt-Jakob disease, variant CJD

Medical dictionary. 2011.

Look at other dictionaries:

  • variant Creutzfeldt-Jakob disease — see ↑Creutzfeldt Jakob disease • • • Main Entry: ↑variance …   Useful english dictionary

  • variant Creutzfeldt-Jakob disease — vCJD; see Creutzfeldt Jakob disease …   The new mediacal dictionary

  • New variant Creutzfeldt-Jakob disease — Abbreviated nvCJD. A human disease thought due to the same infectious agent as bovine spongiform encephalopathy (BSE), or mad cow disease. Both the human and bovine disorders are invariably fatal brain diseases with unusually long incubation… …   Medical dictionary

  • new variant Creutzfeldt-Jakob disease — ► new variant Creutzfeldt Jakob disease a form of the disease possibly linked to BSE. Main Entry: ↑Creutzfeldt Jakob disease …   English terms dictionary

  • new variant Creutzfeldt-Jakob disease — see ↑Creutzfeldt Jakob disease • • • Main Entry: ↑new …   Useful english dictionary

  • new variant Creutzfeldt–Jakob disease — a form of the disease characterized by an early age of onset and possibly linked to BSE. → Creutzfeldt–Jakob disease …   English new terms dictionary

  • Creutzfeldt–Jakob disease — Classification and external resources Tonsil biopsy in variant CJD. Prion Protein immunostaining. ICD 10 A …   Wikipedia

  • Creutzfeldt-Jakob disease — ► NOUN ▪ a fatal degenerative disease affecting nerve cells in the brain. ● new variant Creutzfeldt Jakob disease Cf. ↑new variant Creutzfeldt Jakob disease ORIGIN named after the German neurologists H. G. Creutzfeldt and A. Jakob, who first… …   English terms dictionary

  • Creutzfeldt-Jakob disease — Infobox Disease Name = Creutzfeldt Jakob disease Caption = DiseasesDB = 3166 ICD10 = ICD10|A|81|0|a|80, ICD10|F|02|1|f|00 ICD9 = ICD9|046.1 ICDO = OMIM = 123400 MedlinePlus = eMedicineSubj = neuro eMedicineTopic = 725 MeshID = D007562 Creutzfeldt …   Wikipedia

  • Creutzfeldt-Jakob disease — noun rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control • Syn: ↑CJD, ↑Jakob Creutzfeldt disease • Hypernyms: ↑brain disorder,… …   Useful english dictionary

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