Vitamin B — niacin
Deficiency of niacin, one of the B-complex vitamins, causes pellagra. Pellagra was known as the "disease of the four D's" — dermatitis, diarrhea, dementia and death. The disease is specifically characterized by: Dermatitis: A rash on areas of the skin exposed to light or trauma and ulcerations within the mouth Diarrhea Dementia: Mental disorientation, confusion, delusions and depression Death, if untreated. Pellagra, once a puzzle, was solved by Joseph Goldberger (1874-1929). Serving in the Public Health Service, Dr. Goldberger proposed that pellagra was due to a nutritional deficiency and in 1915 began experiments with Mississippi prison inmates (who "volunteered" in return for full pardons). Dr. Goldberger fed them a poor diet he believed caused pellagra and within months, many developed the disease. Their symptoms of pellagra were reversed when meat, fresh vegetables and milk were added to their diet. Niacin, Dr. Goldberger subsequently showed, was the principle that had this remarkable effect. A readily-available B vitamin, niacin cures pellagra and prevents it. The name "pellagra" comes from the Italian "pelle", skin + "agra", rough = rough skin, referring to the skin problems in pellagra.

Medical dictionary. 2011.

Look at other dictionaries:

  • Vitamin-B — ist eine Vitamin Gruppe, in der acht wasserlösliche Vitamine zusammengefasst sind, die alle als Vorstufen für Koenzyme dienen. Die Nummerierung ist nicht durchgehend, weil sich bei vielen Substanzen, die ursprünglich als Vitamine galten, der… …   Deutsch Wikipedia

  • Vitamin B — ist eine Vitamin Gruppe, in der acht Vitamine zusammengefasst sind, die alle als Vorstufen für Koenzyme dienen. Die Nummerierung ist nicht durchgehend, weil sich bei vielen Substanzen, die ursprünglich als Vitamine galten, der Vitamin Charakter… …   Deutsch Wikipedia

  • vitamin B complex — n a group of water soluble vitamins found esp. in yeast, seed germs, eggs, liver and flesh, and vegetables that have varied metabolic functions and include coenzymes and growth factors called also B complex see BIOTIN, NIACIN …   Medical dictionary

  • vitamin B complex — noun originally thought to be a single vitamin but now separated into several B vitamins • Syn: ↑B complex vitamin, ↑B complex, ↑vitamin B, ↑B vitamin, ↑B • Hypernyms: ↑water soluble vitamin • …   Useful english dictionary

  • vitamin B — noun originally thought to be a single vitamin but now separated into several B vitamins • Syn: ↑B complex vitamin, ↑B complex, ↑vitamin B complex, ↑B vitamin, ↑B • Hypernyms: ↑water soluble vitamin …   Useful english dictionary

  • vitamin B complex — an important group of water soluble vitamins containing vitamin B1, vitamin B2, etc. [1925 30] * * * Water soluble organic compounds with loosely similar properties, distribution in natural sources, and physiological functions. Most are coenzymes …   Universalium

  • Vitamin B — nicotinic acid — Deficiency of nicotinic acid (also known as niacin), one of the B complex vitamins, causes pellagra. Pellagra was known as the disease of the four D s dermatitis, diarrhea, dementia and death. The disease is specifically characterized by:… …   Medical dictionary

  • vitamin B complex — noun Date: 1928 a group of water soluble vitamins that are found especially in yeast, seed germs, eggs, liver and flesh, and vegetables and that have varied metabolic functions and include coenzymes and growth factors called also B complex… …   New Collegiate Dictionary

  • Niacin — IUPAC name …   Wikipedia

  • Vitamin B6 — is a water soluble vitamin. Pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”