Schultz-Dale reaction

Schultz-Dale reaction
Schultz-Dale reaction 'shu̇ltz-'dāl- n a reaction of anaphylaxis carried out in vitro with isolated tissues
Schultz Werner (1878-1947)
German internist. Schultz is best known for his classic description of agranulocytosis in 1922. He did his research on anaphylaxis independently of Dale and carried out his in vitro testing using the intestinal muscles of guinea pigs.
Dale Sir Henry Hallet (1875-1968)
British physiologist and pharmacologist. Dale was one of the outstanding physiologists and pharmacologists of the first half of the 20th century. His early research work centered on the physiological actions of ergot. His work with isolated guinea pig uteri established that the anaphylactic antibodies are attached to cells. He reported on the results of his research on anaphylaxis in 1919. For their discoveries in the chemical transmission of nerve impulses, he and the German pharmacologist Otto Loewi were awarded the Nobel Prize for Physiology or Medicine in 1936.

* * *

see Dale r.

Medical dictionary. 2011.

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  • schultz-dale reaction — ˈshu̇]ltsˈdā(ə)l , ˈshü] noun Usage: usually capitalized S&D Etymology: after Werner Schultz b1878 German physician and Sir Henry Hallett Dale died 1968 English physiologist : a reaction of anaphylaxis carried out in vitro with isolated tissues… …   Useful english dictionary

  • Dale reaction — an in vitro test for anaphylactic sensitization in the guinea pig: a small amount of the antigen added to a tissue bath in which is immersed the excised uterine horn (smooth muscle) of an anaphylactically sensitized guinea pig causes contraction… …   Medical dictionary

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  • Schultz — Werner, German internist, 1878–1947. See S. Charlton phenomenon, S. Charlton reaction, S. Dale reaction. Arthur R.H., German physician, *1890. See S. reaction, S. stain …   Medical dictionary

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