corticotrophin-releasing hormone
- corticotrophin-releasing hormone
a peptide hypothalamic hormone (of 41 amino acids) stimulating the release of
ACTH (
adrenocorticotrophic hormone) from the anterior pituitary. Its own release is suppressed by a
negative feedback loops involving cortisol, and its action is increased by antidiuretic hormone (
see vasopressin) and
angiotensin II. It can be administered intravenously as part of the
CRH test, during which blood is analysed at 15-minute intervals for one hour for the ACTH response, which is excessive in cases of primary adrenal failure and suppressed in cases of anterior
hypopituitarism.
Medical dictionary.
2011.
Look at other dictionaries:
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pituitary gland — hypophysis the master endocrine gland: a pea sized body attached beneath the hypothalamus in a bony cavity at the base of the skull. It has an anterior lobe (adenohypophysis), which secretes thyroid stimulating hormone, ACTH (adrenocorticotrophic … The new mediacal dictionary
ACTH — Abbreviation for adrenocorticotropic hormone. big A. a form of A., produced by certain tumors, which is a larger and more acidic peptide molecule than little A., but is not immunochemically distinguishable from it and does not exert any of the… … Medical dictionary
