A group of peptide antibiotic agents, isolated from several species of Streptomyces (originally Actinomyces), that are active against Gram-positive bacteria, fungi, and neoplasms. Actinomycins are chromopeptides, most containing the chromophore actinocin, and are derivatives of phenoxazine that differ in their amino acid s and their sequence in the peptide chains; they form complexes with DNA and therefore inhibit RNA synthesis, primarily the ribosomal type.
- a. A the first of the actinomycins isolated in crystalline form.
- a. C SYN: cactinomycin.
- a. D SYN: dactinomycin.
- a. F1 KS4; produced by a. C-elaborating strains of Streptomyces chrysomallus; used as an antineoplastic agent.

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ac·ti·no·my·cin -'mīs-ən n any of various red or yellow-red mostly toxic polypeptide antibiotics isolated from soil bacteria (esp. Streptomyces antibioticus) specif one used to inhibit DNA or RNA synthesis

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ac·ti·no·my·cin (ak″tĭ-no-miґsin) a large, complex family of antibiotics obtained from cultures of various species of Streptomyces, which have antibacterial, antifungal, and cytotoxic properties. Actinomycin D (see dactinomycin) is an antineoplastic agent.

Medical dictionary. 2011.

Look at other dictionaries:

  • Actinomycin — D Systematic (IUPAC) name 2 amino N,N bis[(6S,9R,10S,13R,18aS) 6,13 diisopropyl 2,5,9 trimethyl 1,4,7,11,14 pentaoxohexadecahydro 1H pyrrolo[2,1 i] [1,4,7,10,13] oxatetraazacyclohexadecin 10 yl] 4,6 dimethyl 3 oxo 3H …   Wikipedia

  • actinomycin — n. [From actinomyces, the genus of the organism in which they were first found.] 1. any of various red antibiotics isolated from soil bacteria with a three ring heterocyclic nucleus with an attached peptide chain. Note: Actinomycin D is the most… …   The Collaborative International Dictionary of English

  • actinomycin — ☆ actinomycin [ak΄tə nōmī′sin ] n. [< ACTINOMYCETE + IN1] any of various antibiotic polypeptides derived from streptomyces soil bacteria: active against certain bacteria and fungi and some neoplasms …   English World dictionary

  • Actinomycin — Actinomycine sind eine Klasse von Peptid Antibiotika aus Streptomyceten. Inhaltsverzeichnis 1 Struktureller Aufbau 2 Entdeckung und Nomenklatur 3 Biologische Wirkung 4 Pharmakologische Anwendung …   Deutsch Wikipedia

  • actinomycin — noun Date: 1940 any of various red or yellow red mostly toxic polypeptide antibiotics isolated from soil bacteria (especially Streptomyces antibioticus); specifically one used to inhibit DNA or RNA synthesis …   New Collegiate Dictionary

  • actinomycin — /ak tin oh muy sin, ak teuh noh /, n. Pharm. any of a group of related antibiotics derived from several species of streptomyces bacteria, used against susceptible bacteria and fungi and in the treatment of various cancers. [ACTINOMYC(ES) + IN2] * …   Universalium

  • actinomycin — noun Any of a class of toxic polypeptide antibiotics found in soil bacteria of genus Streptomyces …   Wiktionary

  • Actinomycin — Ac|ti|no|my|cin 〈n. 11; Pharm.〉 Antibiotikum, das aus Streptomycesbakterien produziert wird [grch.] * * * Ac|ti|no|my|cin [griech. aktís, Gen.: akti̅nos = Strahl; ↑ mycin], das; s, e: aus Bakterien (Actinomycetales, Strahlenpilze) gewinnbare… …   Universal-Lexikon

  • actinomycin — ac·ti·no·my·cin …   English syllables

  • actinomycin — ac•tin•o•my•cin [[t]ækˌtɪn oʊˈmaɪ sɪn, ˌæk tə noʊ [/t]] n. pha any of a group of related antibiotics derived from streptomyces bacteria, used in the treatment of various cancers • Etymology: 1935–1940; actinomyc (es) + in I …   From formal English to slang

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