- 1. A condensation product of adenine and d-ribose; a nucleoside found among the hydrolysis products of all nucleic acid s and of the various adenine nucleotides. A. accumulates in severe combined immunodeficiency disease. 2. A potent coronary vasodilator used in place of exercise for radionuclide myocardial perfusion studies. SYN: 9-β-d-ribofuranosyladenine.- a. deaminase an enzyme found in mammalian tissues, capable of catalyzing the deamination of a., forming inosine and ammonia. A deficiency of a. deaminase can lead to one form of severe combined immunodeficiency disease.- a. diphosphate a. 5′-diphosphate.- a. kinase enzyme catalyzing the transfer of a phosphate group from MgATP to a., forming MgADP and AMP. An important step in nucleoside salvage.- a. triphosphate SYN: a. 5′-triphosphate.
* * *aden·o·sine ə-'den-ə-.sēn, -sən n a nucleoside C10H13N5O4 that is a constituent of RNA yielding adenine and ribose on hydrolysis
* * *n.a nucleoside that contains adenine and the sugar ribose and occurs in ATP. It is also used as an anti-arrhythmic drug to stop supraventricular tachycardia and restore a normal heart rhythm. As such, it needs to be injected quickly, which may fleetingly make the patient feel faint and develop chest pain. Trade name: Adenocor.
* * *aden·o·sine (ə-denґo-sēn) 1. a purine nucleoside, adenine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid (RNA) and its nucleotides play major roles in the reactions and regulation of metabolism. Symbol A. 2. [USP] a preparation of adenosine, which acts as a cardiac depressant of automaticity in the sinus node and conduction in the atrioventricular node and also as a vasodilator; used as an antiarrhythmic in the treatment of paroxysmal supraventricular tachycardia and as a diagnostic adjunct, in conjunction with myocardial perfusion imaging, to induce coronary artery vasodilation in patients unable to exercise adequately to undergo an exercise stress test; administered intravenously.
Medical dictionary. 2011.