autoimmune hemolytic anemia

autoimmune hemolytic anemia
(AIHA) any of a large group of anemias involving autoantibodies against red cell antigens. Those due to warm-reactive antibodies, usually IgG but occasionally IgM or IgA, may be idiopathic or secondary to autoimmune diseases, hematologic neoplasms, viral infections, or immunodeficiency diseases, and usually involve sequestration of sensitized erythrocytes by the spleen. Those due to cold-reactive antibodies, usually IgM but occasionally IgG, include cold agglutinin syndrome and paroxysmal cold hemoglobinuria and usually involve complement-dependent intravascular hemolysis or sequestration of erythrocytes by the liver.

Medical dictionary. 2011.

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