arachidonate 12-lipoxygenase

arachidonate 12-lipoxygenase
arach·i·don·ate 12-lip·oxy·gen·ase (ə-rakґĭ-don″āt lĭ-pokґsə-jən-ās) [EC 1.13.11.31] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 12 position to form 12-hydroperoxyeicosatetraenoic acid (12-HPETE). The reaction occurs primarily in platelets and is the first step of the lipoxygenase pathway for conversion of arachidonic acid to the leukotriene 12-hydroxyeicosatetraenoic acid (12-HETE).

Medical dictionary. 2011.

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  • Arachidonate 5-lipoxygenase — (5 lipoxygenase, 5 LO or Alox5) is a human enzyme, member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.ubstrates and productsEFA substrates and… …   Wikipedia

  • Arachidonate 12-lipoxygenase — In enzymology, an arachidonate 12 lipoxygenase (EC number|1.13.11.31) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,8Z,10E,14Z) (12S) 12 hydroperoxyicosa 5,8,10,14 tetraenoateThus, the two substrates of… …   Wikipedia

  • Arachidonate 15-lipoxygenase — In enzymology, an arachidonate 15 lipoxygenase (EC number|1.13.11.33) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,8Z,11Z,13E) (15S) 15 hydroperoxyicosa 5,8,11,13 tetraenoateThus, the two substrates of… …   Wikipedia

  • Arachidonate 8-lipoxygenase — In enzymology, an arachidonate 8 lipoxygenase (EC number|1.13.11.40) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,9E,11Z,14Z) (8R) 8 hydroperoxyicosa 5,9,11,14 tetraenoateThus, the two substrates of… …   Wikipedia

  • arachidonate 5-lipoxygenase — arach·i·don·ate 5 lip·oxy·gen·ase (ə rak″ĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.34] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 5 position to form 5… …   Medical dictionary

  • arachidonate 15-lipoxygenase — arach·i·don·ate 15 lip·oxy·ge·nase (ə rakґĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.33] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 15 position to form 15… …   Medical dictionary

  • Lipoxygenase — Pfam box Symbol = Lipoxygenase Name = width =220 caption = Arachidonate 15 Lipoxygenase Pfam= PF00305 InterPro= IPR013819 SMART= PROSITE = PDOC00077 SCOP = 2sbl TCDB = OPM family= 87 OPM protein= 1zq4 PDB=PDB3|1y4kA:155 823 PDB3|2sblB:155 823… …   Wikipedia

  • Lipoxygenase inhibitor — A Lipoxygenase inhibitor is a drug which slows down or stops the action of the lipoxygenase enzyme. More precisely, the term is almost always used to describe an inhibitor of the arachidonate 5 lipoxygenase enzyme, which transforms EFAs into… …   Wikipedia

  • 5-lipoxygenase — arachidonate 5 lipoxygenase …   Medical dictionary

  • 12-lipoxygenase — arachidonate 12 lipoxygenase …   Medical dictionary

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