amyotrophic lateral sclerosis–parkinsonism–dementia complex

amyotrophic lateral sclerosis–parkinsonism–dementia complex
an autosomal dominant disorder caused by mutation in the TRPM7 gene (locus: 15q21), which encodes a protein that functions as an ion channel and a kinase; it occurs among the Chamorro population of Guam and is characterized by gradually progressing parkinsonism associated with progressive dementia and amyotrophic lateral sclerosis.

Medical dictionary. 2011.

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  • lytico-bodig disease — [lytico bodig, a local name for the disease, formed from truncations of Sp. paralitico paralytic and bodega small store] amyotrophic lateral sclerosis–parkinsonism–dementia complex …   Medical dictionary

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