anti-inhibitor coagulant complex


anti-inhibitor coagulant complex
(AICC) a concentrated fraction from pooled human plasma, which includes vitamin K–dependent coagulation factors (factors II, VII, IX, X), factors of the kinin-generating system, and factor VIII coagulant antigen. It is administered intravenously as an antihemorrhagic in hemophilic patients with factor VIII inhibitors; its mechanism of action has not been elucidated but may be due at least in part to its factor Xa content. Called also activated prothrombin complex concentrate.

Medical dictionary. 2011.

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