transient myeloproliferative disorder


transient myeloproliferative disorder
usually transient leukocytosis associated with Down syndrome and generally diagnosed in the first few weeks of life, often with hepatosplenomegaly, pericardial and pleural effusions, hepatic disease, and a pustular rash. Although spontaneous remission occurs in most cases, some affected infants develop a myelodysplastic syndrome or acute leukemia. Called also congenital leukemoid reaction and transient leukemia of infancy.

Medical dictionary. 2011.

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