eosinophil chemotactic factor of anaphylaxis

eosinophil chemotactic factor of anaphylaxis
(ECF-A) eosinophil chemoattractants released by basophils and mast cells in immediate hypersensitivity reactions. ECF-A activity is associated with two acidic tetrapeptides (Ala-Gly-Ser-Glu and Val-Gly-Ser-Glu) and with less well characterized larger peptides, which are chemotactic for eosinophils and, to a lesser degree, for neutrophils. Some ECF-A activity is due to arachidonic acid metabolites (leukotriene B, 12-HETE, and 12-HHT). Called also eosinophil chemotactic f. (ECF).

Medical dictionary. 2011.

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