fatty-acid synthase

fatty-acid synthase
fat·ty-ac·id syn·thase (fatґe asґid sinґthās) [EC 2.3.1.85] an enzyme complex that catalyzes the synthesis of long-chain fatty acids. Two-carbon units are successively added to the growing chain in a process similar to fatty acid oxidation in reverse, with each unit added via a series of condensation and decarboxylation, reduction, and dehydration reactions. The overall reaction is: acetyl CoA + n malonyl CoA + 2n NADPH = long-chain fatty acid anion + n CO2 + 2n NADP+ + (n + 1) CoA. Palmitate is the preferred product of the mammalian liver enzyme complex, which includes catalytic sites for the seven sequential reactions.

Medical dictionary. 2011.

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  • Fatty acid synthase — (FAS) is enzymatic system composed of 272 kDa multifunctional polypeptide, in which substrates are handed from one functional domain to the next [Alberts, A.W., Strauss, A.W., Hennessy, S. Vagelos, P.R. Regulation of synthesis of hepatic fatty… …   Wikipedia

  • Fatty-acid synthase — In enzymology, a fatty acid synthase (EC number|2.3.1.85) is an enzyme that catalyzes the chemical reaction:acetyl CoA + n malonyl CoA + 2n NADPH + 2n H+ ightleftharpoons a long chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+The 4 substrates of… …   Wikipedia

  • Fatty acid synthase — Acide gras synthase L Acide gras synthase est un complexe multienzymatique (dimère d enzymes sous forme antiparallèles dépendant de l acide pantothénique et du Coenzyme A), aussi connu sous le nom de FAS (Fatty Acid Synthase). Il est formé par 2… …   Wikipédia en Français

  • Fatty acid metabolism — Fatty acids are an important source of energy for many organisms. Excess glucose can be stored efficiently as fat. Triglycerides yield more than twice as much energy for the same mass as do carbohydrates or proteins. All cell membranes are built… …   Wikipedia

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  • Fatty acid — One of many molecules that are long chains of lipid carboxylic acid found in fats and oils and in cell membranes as a component of phospholipids and glycolipids. (Carboxylic acid is an organic acid containing the functional group COOH.) Fatty… …   Medical dictionary

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  • Delta12-fatty acid dehydrogenase — Identifiers EC number 1.14.99.33 Databases IntEnz IntEnz vi …   Wikipedia

  • Fatty-acyl-CoA synthase — In enzymology, a fatty acyl CoA synthase (EC number|2.3.1.86) is an enzyme that catalyzes the chemical reaction:acetyl CoA + n malonyl CoA + 2n NADH + 2n NADPH + 4n H+ ightleftharpoons long chain acyl CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+The 3 …   Wikipedia

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