A lysosomal disorder due to deficiency of aspartoglucosaminidase, resulting in accumulation of aspartlyglycosamine in the urine and spinal fluid; characterized by symptoms usually in the first few months of life, with recurrent infections and diarrhea; mental retardation, seizures, coarse facial features, and skeletal abnormalities are evident by adolescence. Autosomal recessive inheritance, caused by mutation in the aspartoglucosaminidase gene (AGA) on 4q.

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as·par·tyl·gly·cos·a·mi·nu·ria (ə-spahrґtəl-gliґkōs-ə-min-uґre-ə) aspartylglucosaminuria.

Medical dictionary. 2011.

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  • aspartylglycosaminidase — A hydrolytic enzyme that cleaves off l aspartate from aspartylglycosamines. A deficiency of a. can result in aspartylglycosaminuria. * * * as·par·tyl·gly·cos·amin·i·dase (ə spahr″təl gli kōs″ə minґĭ dās)… …   Medical dictionary

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  • aspartylglucosamine — as·par·tyl·glu·co·sa·mine (ə spahr″təl gloo kōsґə mēn) N acetylglucosamine in N glycosidic linkage with the amino group of asparagine; it is an intermediate in the degradation of glycoproteins and accumulates… …   Medical dictionary

  • aspartylglucosaminidase — as·par·tyl·glu·co·sa·min·i·dase (ə spahr″təl gloo kōs″ə minґĭ dās) a lysosomal enzyme of the hydrolase class that catalyzes the cleavage of N glycosidic linkages between N acetylglucosamine and asparagine …   Medical dictionary

  • aspartylglucosaminuria — as·par·tyl·glu·co·sa·min·uria (ə spahr″təl gloo″kōs am″in uґre ə) a severe autosomal recessive lysosomal storage disease caused mutations in the AGA gene (locus: 4q32 q33), which encodes… …   Medical dictionary

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