fructose-26-bisphosphate 2-phosphatase

fructose-26-bisphosphate 2-phosphatase
fruc·tose-2,6-bis·phos·phate 2-phos·pha·tase (frookґtōs bis-fosґfāt fosґfə-tās) [EC 3.1.3.46] an enzyme activity that catalyzes the hydrolysis of fructose 2,6-bisphosphate to form fructose 6-phosphate; it occurs on the same polypeptide as the enzyme activity 6-phosphofructo-2-kinase (q.v.); in liver, the two activities form part of a mechanism for regulating carbohydrate metabolism. The liver enzyme activity is activated via phosphorylation by cyclic-AMP–dependent protein kinase, thus increasing the rate of removal of fructose 2,6-bisphosphate and slowing glycolysis. Called also fructose-2,6-bisphosphatase.

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