BRCA gene

BRCA gene
[breast cancer] either of two tumor suppressor genes, BRCA1 and BRCA2, that encode ubiquitously expressed nuclear proteins involved in regulation of DNA repair, transcriptional activation, and the cell cycle; germline mutations of either gene are associated with inherited predisposition to ovarian and female breast cancers. BRCA1 mutations also confer an increased risk for prostate and colon cancers and BRCA2 for prostate, pancreatic, bile duct, gallbladder, and male breast cancers.

Medical dictionary. 2011.

Look at other dictionaries:

  • BRCA gene — /bi a si ˈeɪ dʒin/ (say bee ah see ay jeen) noun a gene which is involved in tumour suppression, helping to ensure the stability of the cell s genetic material, but which may mutate into genes known as BRCA1 or BRCA2, inheritable harmful… …   Australian English dictionary

  • Gene — The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function. An official definition: According to the official Guidelines for Human Gene Nomenclature, a gene is defined as a DNA segment that… …   Medical dictionary

  • BRCA 1 — BRCA1 Le gène BRCA1 (acronyme de BReast CAncer n°1 cancer du sein n°1 à début précoce) est un gène humain qui appartient à une classe de gènes suppresseurs de tumeur, qui maintiennent l intégrité génomique afin de prévenir la prolifération… …   Wikipédia en Français

  • BRCA-1 — Die Lage des BRCA1 Gens auf Chromosom 17 Schematische Darstellung des BRCA1 Polypeptides BRCA1 (BReast CAncer 1, early onset; deutsch: Brustkrebs 1 …   Deutsch Wikipedia

  • Brca — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom.   Sigles d’une seule lettre   Sigles de deux lettres   Sigles de trois lettres > Sigles de quatre lettres …   Wikipédia en Français

  • BRCA-2 — Das Modell des BRCA2 Peptids BRCA2 (BReast CAncer 2, early onset; deutsch: Brustkrebs 2, Manifestation im Kindesalter), in einigen Publikationen auch als Brustkrebsgen 2 bezeichnet, ist ein menschliches Gen, welches zur Klasse der… …   Deutsch Wikipedia

  • brca — (= breast cancer related gene) Two genes (BRCA 1 and BRCA 2) associated with familial breast carcinoma have now been identified …   Dictionary of molecular biology

  • BRCA — breast cancer * * * BRCA .bē (.)är (.)sē ā n either of two tumor supressor genes that in mutated form tend to be associated with an increased risk of certain cancers and esp. breast and ovarian cancers * * * see under gene …   Medical dictionary

  • Ovarian cancer — (human) Classification and external resources Micrograph of a low malignant potential mucinous ovarian tumour. H E stain. ICD 10 …   Wikipedia

  • Epidemiology and etiology of breast cancer — Epidemiological risk factors for a disease can provide important clues as to the etiology, or cause, of a disease. The first work on the epidemiology and etiology of breast cancer was done by Janet Lane Claypon, who published a comparative study… …   Wikipedia