SHH gene

SHH gene
[Sonic Hedgehog; from the animated character] a human gene homologous to the Drosophila hedgehog gene, which is required for embryonic segmentation; it encodes a dosage-sensitive signaling molecule that induces and organizes development of cells and tissues, including the brain and spinal cord and the limb buds. Mutations have been associated with holoprosencephaly.

Medical dictionary. 2011.

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  • Holoprosencephaly — A disorder characterized by the failure of the prosencephalon (the forebrain of the embryo) to develop. During normal development, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of pregnancy. Holoprosencephaly …   Medical dictionary

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