focal glomerulosclerosis

focal segmental glomerulosclerosis the occurrence of focal sclerosing lesions of the renal glomeruli, marked by proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another disease, such as heroin-abuse nephropathy, chronic interstitial nephritis, or a malignancy. Exacerbations and remissions may occur, most often in children; progression to renal failure occurs at a variable and unpredictable rate. Called also focal glomerular sclerosis.