glutamate decarboxylase

glutamate decarboxylase
glu·ta·mate de·car·box·y·lase (glooґtə-māt de-kahr-bokґsə-lās) [EC 4.1.1.15] an enzyme of the lyase class that catalyzes the decarboxylation of glutamate to form γ-aminobutyrate (GABA). The enzyme is a pyridoxal phosphate protein, and the reaction occurs within the mitochondria in kidney, and outside the mitochondria in brain. Deficiency of the brain enzyme may be the cause of convulsions that begin in infancy and are responsive to pyridoxine therapy. Called also glutamic acid decarboxylase.

Medical dictionary. 2011.

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