hydroxyeicosatetraenoic acid

hydroxyeicosatetraenoic acid
(HETE) hy·droxy·ei·co·sa·tet·ra·eno·ic ac·id (HETE) (hi-drok″se-i-ko″sə-tet″rə-e-noґik) any of several arachidonic acid metabolites produced by lipoxygenases from hydroperoxyeicosatetraenoic acid. 5-HETE is a byproduct of leukotriene metabolism. 12-HETE and 5,12-HETE are chemotactic for neutrophils and eosinophils and 12-HETE and 15-HETE may inhibit leukotriene production.

Medical dictionary. 2011.

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  • hydroxyeicosatetraenoic acid — noun A hydroxy derivative of a polyunsaturated fatty acid; it is an intermediate in the biosynthesis of leukotrienes …   Wiktionary

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  • HETE — Hydroxyeicosatetraenoic acid (Ácido hidroxieicosatetraenoico) …   Diccionario de siglas médicas y otras abreviaturas

  • lipoxygenase pathway — a pathway for the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid. It is initiated by oxidation of arachidonic acid by arachidonate lipoxygenases, and the reactions occur in the cytosol of leukocytes, mast cells …   Medical dictionary

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  • Arachidonate 5-lipoxygenase — (5 lipoxygenase, 5 LO or Alox5) is a human enzyme, member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.ubstrates and productsEFA substrates and… …   Wikipedia

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