hypoxanthine phosphoribosyltransferase

hypoxanthine phosphoribosyltransferase
(HPRT) hy·po·xan·thine phos·pho·ri·bo·syl·trans·fer·ase (HPRT) (hi″po-zanґthēn fos″fo-ri″bo-səl-transґfər-ās) [EC] an enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine or guanine to its corresponding nucleoside monophosphate, a salvage mechanism for recovery of preformed purines, especially in the central nervous system. Absence of enzyme activity, an X-linked trait, results in Lesch-Nyhan syndrome; partially decreased enzyme activity results in hyperuricemia and severe gouty arthritis without the neurologic sequelae of Lesch-Nyhan syndrome. Called also hypoxanthine-guanine phosphoribosyltransferase.

Medical dictionary. 2011.

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  • Hypoxanthine-guanine phosphoribosyltransferase — (HPRTcite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene cmd=retrieve dopt=default list uids=3251 rn=1 |title=Entrez Gene: hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)] ) is an enzyme in purine metabolism. PBB… …   Wikipedia

  • hypoxanthine-guanine phosphoribosyltransferase — hy·po·xan·thine gua·nine phos·pho·ri·bo·syl·trans·fer·ase gwän .ēn .fäs fō .rī bō sil tran(t)s (.)fər .ās, .āz n an enzyme that conserves hypoxanthine in the body by limiting its conversion to uric acid and that is lacking in Lesch Nyhan syndrome …   Medical dictionary

  • Phosphoribosyltransferase — may refer to: * Adenine phosphoribosyltransferase * Hypoxanthine guanine phosphoribosyltransferase * Orotidine 5 phosphate decarboxylase * Uracil phosphoribosyltransferase …   Wikipedia

  • hypoxanthine guanine phosphoribosyltransferase — hypoxanthine guanine phosphoribosyltransferase. См. гипоксантингуанин фосфорибозилтрансфераза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Hypoxanthine — Chembox new ImageFile=Hypoxanthin Hypoxanthine.svg ImageSize= IUPACName=3,7 dihydropurin 6 one OtherNames= Section1= Chembox Identifiers CASNo=68 94 0 PubChem=790 SMILES=O=C1NC=Nc2nc [nH] c12 MeSHName=Hypoxanthine Section2= Chembox Properties… …   Wikipedia

  • hypoxanthine — 6 Oxypurine; purin 6(1H) one; a purine present in the muscles and other tissues, formed during purine catabolism by deamination of adenine; elevated in molybdenum cofactor deficiency. SYN: 6 hydroxypurine. h. guanine phosphoribosyltransferase ( …   Medical dictionary

  • phosphoribosyltransferase — One of a group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d ribose 5 phosphate from 5 phospho α d ribosyl pyrophosphate to a purine, pyrimidine, or pyridine acceptor, forming a 5′ nucleotide and pyrophosphate, or d ribose from d …   Medical dictionary

  • Adenine phosphoribosyltransferase — Adenine phosphoribosyltransferase, also known as APRT, is a human gene.cite web | title = Entrez Gene: APRT adenine phosphoribosyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=353| accessdate …   Wikipedia

  • Hypoxanthin-Guanin-Phosphoribosyltransferase — Hypoxanthin Guanin Phosphoribosyl Transferase …   Deutsch Wikipedia

  • HPRT — • hypoxanthine phosphoribosyltransferase …   Dictionary of medical acronyms & abbreviations

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