L-lactate dehydrogenase

L-lactate dehydrogenase
L-lac·tate de·hy·dro·gen·ase (LDH) (lakґtāt de-hiґdro-jən-ās) [EC 1.1.1.27] an enzyme of the oxidoreductase class that catalyzes the reduction of pyruvate to (S)-lactate, using NADH as an electron donor. The reaction is the final step in glycolysis (white fibers). The reverse reaction is the first step in the combustion of lactate (heart, red fibers) or its conversion to glucose (liver). The enzyme occurs in the cytoplasm of nearly all cells. It is a tetramer containing M (muscle) and H (heart) subunits; it exists as five distinct isozymes (M4, M3H, M2H2, MH3, H4). Identification of isozyme types in serum is used for clinical diagnosis.

Medical dictionary. 2011.

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  • lactate dehydrogenase — noun Date: 1966 any of a group of isoenzymes that catalyze reversibly the conversion of pyruvic acid to lactic acid called also lactic dehydrogenase …   New Collegiate Dictionary

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