cell-mediated lympholysis

cell-mediated lympholysis
(CML) a variation of the mixed lymphocyte culture (MLC) that is a functional test of the ability of cytotoxic T lymphocytes to kill target cells. Lymphocytes from two individuals are cultured together for several days, one population having been prevented from proliferating by treatment with radiation or mitomycin (a “one-way” MLC); they are then cultured for several hours with 51Cr-labeled target cells that are HLA-identical to the stimulator cells. Cytotoxicity is measured as percentage of 51Cr released from specific target cells compared to percentage of 51Cr released from control (nonspecific target) cells.

Medical dictionary. 2011.

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  • cell-mediated lympholysis assay — (CML assay) see under lympholysis …   Medical dictionary

  • CML assay — cell mediated lympholysis a.; see under lympholysis …   Medical dictionary

  • CML — 1. Abbreviation for cell mediated lymphocytotoxicity. 2. Acronym for chronic myelogenous leukemia. * * * carboxymethyl lysine; cell mediated lymphocytotoxicity; cell mediated lympholysis; central motor latency; chronic myelocytic leukemia;… …   Medical dictionary

  • CML — • carboxymethyl lysine; • cell mediated lymphocytotoxicity; • cell mediated lympholysis; • central motor latency; • chronic myelocytic leukemia; • chronic myelogenous leukemia; • clinical medical librarian; • clinical medical library …   Dictionary of medical acronyms & abbreviations

  • CML — (1) Cell mediated lympholysis: the process of target cell lysis by CMCs. (2) Chronic myeloid leukaemia …   Dictionary of molecular biology

  • ANAPC4 — Anaphase promoting complex subunit 4, also known as ANAPC4, is a human gene.cite web | title = Entrez Gene: ANAPC4 anaphase promoting complex subunit 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=29945| …   Wikipedia

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