mitogen-activated protein kinase

mitogen-activated protein kinase
(MAPK) mi·to·gen-ac·ti·vat·ed pro·tein ki·nase (MAPK) (miґto-jən akґtĭ-vāt-əd proґtēn kiґnās) [EC 2.7.11.24] any of a group of protein-serine/threonine kinases that when activated enter the cell nucleus and catalyze the phosphorylation of serine and threonine residues in transcription factors that regulate gene expression; it is the final member of a signal transduction cascade of three protein kinases that is initiated by stimulation of a wide variety of membrane receptors and is important in the regulation of cell growth and differentiation. Called also MAP kinase.

Medical dictionary. 2011.

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