idiotype–anti-idiotype network


idiotype–anti-idiotype network
a regulatory mechanism mounted in response to the unique or idiotypic determinants of lymphocytes or antibodies upon antigenic stimulation. Activation of a B cell results in a clone of plasma cells producing immunoglobulin of a single idiotype, which, because it was previously present in very small quantities, can be recognized as “nonself” and results in the production of anti-idiotypic antibodies directed against its idiotypic determinants. There can also be anti–anti-idiotypic antibodies directed against the second antibodies, antibodies directed against them, and so forth. These antibodies react with antigen receptors on B cells and T helper and suppressor cells, as well as with circulating antibodies, to enhance or suppress production of the initial antibody by various mechanisms.

Medical dictionary. 2011.

Look at other dictionaries:

  • anti-idiotype — an·ti id·io·type (an″te idґe o tīp) an antibody directed against an idiotypic determinant of another antibody. See idiotype–anti idiotype network, under network …   Medical dictionary

  • immunoregulation — im·mu·no·reg·u·la·tion (im″u no reg″u laґshən) control of the immune response by mechanisms such as suppressor and contrasuppressor lymphocyte circuits and the immunoglobulin idiotype–anti idiotype network …   Medical dictionary


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