lectin pathway


lectin pathway
a pathway of complement activation initiated in the absence of antibody by the binding of mannose-binding lectin (MBL) to carbohydrates on the surface of microorganisms. MBL in turn activates complement component C4; the rest of the steps are the same as those of the classical pathway.

Medical dictionary. 2011.

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  • Mannan-binding lectin pathway — Natta projection of mannose in its α D mannopyranose form. Mannan is a polymer of mannose. The Mannan binding lectin pathway (also known simply as the Lectin Pathway) is similar in structure to the classical complement pathway,[1] …   Wikipedia

  • lectin complement pathway — (lek tin) The lectin pathway for complement activation is triggered by the binding of a serum lectin (mannan binding lectin; MBL) to mannose containing proteins or to carbohydrates on viruses or bacteria …   Dictionary of microbiology

  • Lectin — Lectins are sugar binding proteins which are highly specific for their sugar moieties. They typically play a role in biological recognition phenomena involving cells and proteins. For example, some bacteria use lectins to attach themselves to the …   Wikipedia

  • Mannan-binding lectin — Mannose binding lectin (protein C) 2, soluble PDB rendering based on 1hup …   Wikipedia

  • Alternative complement pathway — The classical and alternative complement pathways. Alternative pathway …   Wikipedia

  • mannose-binding lectin — (MBL) a protein that is structurally similar to complement component C1 and recognizes many microorganisms, including bacteria, fungi, parasites, and viruses. It initiates the lectin pathway of complement activation, without the presence of… …   Medical dictionary

  • Complement system — This article is about an aspect of the immune system. For other uses, see complement (disambiguation). The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of… …   Wikipedia

  • FCN3 — Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen), also known as FCN3, is a human gene.cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url =… …   Wikipedia

  • Map44 — mannan binding lectin serine peptidase 1 (C4/C2 activating component of Ra reactive factor) Identifiers Symbol MASP1 Alt. symbols CRARF, PRSS5 Entrez …   Wikipedia

  • FCN2 — Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), also known as FCN2, is a human gene.cite web | title = Entrez Gene: FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)| url =… …   Wikipedia


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