carbidopa

carbidopa
A dopa decarboxylase inhibitor which does not enter the brain used in conjunction with levodopa in the treatment of Parkinson disease to reduce L-dopa doses and reduce side effect s.

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car·bi·do·pa .kär-bə-'dō-pə n a drug C10H14N2O4·H2O that inhibits decarboxylation of L-dopa in tissues outside the brain and that is administered with, L-dopa in the treatment of Parkinson's disease to increase the amount of, L-dopa available for transport to the brain

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car·bi·do·pa (kahr″bĭ-doґpə) [USP] an inhibitor of the decarboxylation of peripheral levodopa to dopamine, which does not penetrate the central nervous system. When given with levodopa, carbidopa produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. It is used orally, in conjunction with levodopa, as an antiparkinsonian agent.

Medical dictionary. 2011.

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  • carbidopa — inhibidor de la decarboxilasa que no atraviesa la barrera hematoencefálica y, por tanto, solo actúa periféricamente. Se utiliza en el tratamiento de la enfermedad de Parkinson, conjuntamente con la levodopa estructura química [véase… …   Diccionario médico

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  • Carbidopa — drugbox IUPAC name = (2 S ) 3 (3,4 dihydroxyphenyl) 2 hydrazinyl 2 methyl propanoic acid CAS number = 28860 95 9 ATC prefix = ATC suffix = ATC supplemental = PubChem = 34359 DrugBank = APRD00160 C=10 | H=14 | N=2 | O=4 molecular weight = 226.229… …   Wikipedia

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  • carbidopa — n.; see levodopa …   The new mediacal dictionary

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