type I


type I
a hypersensitivity reaction that occurs within minutes when a sensitized individual is reexposed to antigen, resulting from interaction of IgE and the antigen; clinical manifestations can range from localized dermatitis, urticaria, or angioedema to allergic rhinitis or asthma to systemic anaphylaxis. The first exposure to the antigen induces the production of IgE antibodies that bind to receptors on mast cells and basophils. Upon subsequent exposure the antigen cross-links receptor-bound IgE molecules, triggering production and release of a diverse array of mediators that act on other cells, producing symptoms such as bronchospasm, edema, mucous secretion, and inflammation. Called also immediate hypersensitivity r.

Medical dictionary. 2011.

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