receptor protein-tyrosine kinase


receptor protein-tyrosine kinase
re·cep·tor pro·tein-ty·ro·sine ki·nase (re-sepґtər proґtēn tiґro-sēn kiґnās) [EC 2.7.10.1] a group comprising those protein-tyrosine kinases with a transmembrane domain and cytoplasmic tyrosine kinase activity. They are involved in cellular signaling pathways; binding of extracellular growth factor ligands (e.g., epidermal growth factor, fibroblast growth factors, transforming growth factor-α, platelet-derived growth factor, insulin) leads to dimerization and activation of receptors, autophosphorylation, and then binding and activation of effector proteins that control cellular proliferation and differentiation. Cf. non-specific protein-tyrosine kinase.

Medical dictionary. 2011.

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  • protein-tyrosine kinase — pro·tein ty·ro·sine ki·nase (proґtēn tiґro sēn kiґnās) [EC 2.7.10] a group comprising the protein kinases that catalyze the phosphorylation of tyrosine residues in specific proteins. It is subdivided into the receptor protein… …   Medical dictionary

  • non-specific protein-tyrosine kinase — non spe·cif·ic pro·tein ty·ro·sine ki·nase (non″spə sifґik proґtēn tiґro sēn kiґnās) [EC 2.7.10.2] a group comprising those protein tyrosine kinases that lack a transmembrane domain. They are further divided into… …   Medical dictionary

  • Non-specific protein-tyrosine kinase — In enzymology, a non specific protein tyrosine kinase (EC number|2.7.10.2) is an enzyme that catalyzes the chemical reaction:ATP + a [protein] L tyrosine ightleftharpoons ADP + a [protein] L tyrosine phosphateThus, the two substrates of this… …   Wikipedia

  • Protein tyrosine phosphatase — Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post translational modification that can create novel… …   Wikipedia

  • Receptor tyrosine kinase — Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Of the ninety unique tyrosine kinase genes idenitified in the human genome, 58 encode receptor tyrosine… …   Wikipedia

  • Tyrosine kinase 2 — Tyrosine kinase 2, also known as TYK2, is a human gene.cite web | title = Entrez Gene: TYK2 tyrosine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7297| accessdate = ] Tyk2 was the first member… …   Wikipedia

  • Tyrosine kinase — A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important… …   Wikipedia

  • tyrosine kinase — Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand binding domain, a single… …   Dictionary of molecular biology

  • Non-receptor tyrosine kinase — non membrane spanning protein tyrosine kinase Identifiers EC number 2.7.10.2 Databases IntEnz In …   Wikipedia

  • Megakaryocyte-associated tyrosine kinase — PDB rendering based on 1jwo …   Wikipedia


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