saccharopine dehydrogenase

saccharopine dehydrogenase
sac·cha·ro·pine de·hy·dro·gen·ase (sakґə-ro-pēn″ de-hiґdro-jən-ās) an enzyme activity that catalyzes oxidative cleavage of saccharopine to form α-aminoadipate semialdehyde and glutamate, using NAD+ as an electron acceptor. The reaction is the second step in the major route of lysine degradation; the enzyme activity is part of the bifunctional enzyme α-aminoadipic semialdehyde synthase (q.v.). Enzyme activity is absent in hyperlysinemia and the variant saccharopinuria. In official nomenclature called saccharopine dehydrogenase (NAD+, L-glutamate-forming).

Medical dictionary. 2011.

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  • Saccharopine dehydrogenase — protein Name=saccharopine dehydrogenase (putative) caption= width= HGNCid=24275 Symbol=SCCPDH AltSymbols= EntrezGene=51097 OMIM= RefSeq=NM 016002 UniProt=Q8NBX0 PDB= ECnumber= Chromosome=1 Arm=q Band=44 LocusSupplementaryData=Saccharopine… …   Wikipedia

  • Saccharopine dehydrogenase (NAD+, L-glutamate-forming) — In enzymology, a saccharopine dehydrogenase (NAD+, L glutamate forming) (EC number|1.5.1.9) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NAD+ + H2O ightleftharpoons L glutamate + 2 aminoadipate 6… …   Wikipedia

  • Saccharopine dehydrogenase (NADP+, L-glutamate-forming) — In enzymology, a saccharopine dehydrogenase (NADP+, L glutamate forming) (EC number|1.5.1.10) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NADP+ + H2O ightleftharpoons L glutamate + L 2 aminoadipate 6… …   Wikipedia

  • Saccharopine dehydrogenase (NAD+, L-lysine-forming) — In enzymology, a saccharopine dehydrogenase (NAD+, L lysine forming) (EC number|1.5.1.7) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NAD+ + H2O ightleftharpoons L lysine + 2 oxoglutarate + NADH + H+The… …   Wikipedia

  • Saccharopine dehydrogenase (NADP+, L-lysine-forming) — In enzymology, a saccharopine dehydrogenase (NADP+, L lysine forming) (EC number|1.5.1.8) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NADP+ + H2O ightleftharpoons L lysine + 2 oxoglutarate + NADPH +… …   Wikipedia

  • saccharopine dehydrogenase (NAD+ L-glutamate-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NAD+, L glu·ta·mate form·ing) (sakґə ro pēn″ de hiґdro jən ās glooґtə māt formґing) [EC 1.5.1.9] official nomenclature for saccharopine dehydrogenase …   Medical dictionary

  • saccharopine dehydrogenase (NADP+ L-lysine-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NADP+, L ly·sine form·ing) (sakґə ro pēn″ de hiґdro jən ās liґsēn formґing) [EC 1.5.1.8] official nomenclature for lysine ketoglutarate reductase …   Medical dictionary

  • Saccharopine — Chembox new ImageFile=Saccharopine.gif ImageSize=125px IUPACName=2 [(5 amino 5 carboxy pentyl) amino] pentanedioic acid OtherNames= Section1= Chembox Identifiers CASNo=997 68 2 PubChem=1087 SMILES=C(CCNC(CCC(=O)O)C(=O)O)CC(C(=O)O)N… …   Wikipedia

  • saccharopine — A derivative of α ketoglutarate and l lysine that is an intermediate in l lysine catabolism; elevated in cases of saccharopinuria. s. dehydrogenase two enzymes that are used in the pathway of l lysine catabolism; the first isoform catalyzes the… …   Medical dictionary

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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