glycerol phosphate shuttle


glycerol phosphate shuttle
a cyclic mechanism for transferring electrons from cytosolic NADH to the mitochondrial electron transport chain and thus to oxygen, acting by means of enzyme-catalyzed redox reactions that interconvert glycerol 3-phosphate and dihydroxyacetone phosphate. It occurs primarily in white fibers of striated muscle and nervous tissue. See illustration.

Glycerol phosphate shuttle.


Medical dictionary. 2011.

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  • Glycerol phosphate shuttle — The glycerol 3 phosphate shuttle is a mechanism that regenerates NAD+ from NADH, a by product of glycolysis. Its importance in transporting reducing equivalents is secondary to the malate aspartate shuttle.ReactionIn this shuttle, the enzyme… …   Wikipedia

  • glycerol phosphate — (L )glycerol 3 phosphate an intermediate in the glycerol phosphate shuttle, in the utilization of glycerol, and in the biosynthesis of lipids …   Medical dictionary

  • Glycerol-3-phosphate dehydrogenase — protein Name=glycerol 3 phosphate dehydrogenase 1 (soluble) caption= width= HGNCid=4455 Symbol=GPD1 AltSymbols= EntrezGene=2819 OMIM=138420 RefSeq=NM 005276 UniProt=P21695 PDB= ECnumber=1.1.1.8 Chromosome=12 Arm=q Band=12 LocusSupplementaryData=… …   Wikipedia

  • glycerol-3-phosphate dehydrogenase — α Glycerol phosphate dehydrogenase; 3 phosphoglycerol dehydrogenase; a flavoenzyme that catalyzes the interconversion of dihydroxyacetone phosphate and sn glycerol 3 phosphate, with the participation of NAD+; its action provides the glycerol… …   Medical dictionary

  • glycerol-3-phosphate dehydrogenase (NAD+) — glyc·er·ol 3 phos·phate de·hy·dro·gen·ase (NAD+) (glisґər ol fosґfāt de hiґdro jən ās) [EC 1.1.1.8] a cytosolic enzyme of the oxidoreductase class that catalyzes the oxidation of glycerol 3 phosphate to dihydroxyacetone… …   Medical dictionary

  • Glycerol 3-phosphate — Chembox new ImageFile = glycerol 3 phosphate.png ImageSize = 150px IUPACName = 1,2,3 Propanetriol, 1 (dihydrogen phosphate) OtherNames = Glycerol 1 phosphate Glycerophosphate α glycerolphosphate Section1 = Chembox Identifiers CASNo = 57 03 4… …   Wikipedia

  • shuttle — A going back and forth regularly; used in respect to certain transport processes across a biomembrane. glycerophosphate s. a mechanism for the transfer of reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize …   Medical dictionary

  • Mitochondrial shuttle — The mitochondrial shuttles are systems used to transport reducing agents across the inner mitochondrial membrane. NADH cannot cross the membrane, but it can reduce another molecule that can cross the membrane, so that its electrons can reach the… …   Wikipedia

  • Malate-aspartate shuttle — Diagram Illustrating the Malate Asparate Shuttle Pathway The malate aspartate shuttle (sometimes also the malate shuttle) is a biochemical system for translocating electrons produced during glycolysis across the semipermeable inner membrane of… …   Wikipedia

  • dihydroxyacetone phosphate — an intermediate in glycolysis, the glycerol phosphate shuttle, and the biosynthesis of carbohydrates and of lipids …   Medical dictionary