cherry-red spot

cherry-red spot
a red circular area (the choroid) surrounded by gray-white retina, seen through the fovea centralis of the eye in Tay-Sachs disease and several other neurodegenerative storage diseases. It is caused by accumulation of sphingolipids in retinal ganglion cells, giving a whitish appearance to areas with such cells; the parafoveal area has many, while the fovea has none. Called also Tay s. or sign. See illustration at Tay-Sachs disease, under disease.

Medical dictionary. 2011.

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